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KMID : 0356720070230020071
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Journal of the Korean Society of Coloproctology
2007 Volume.23 No. 2 p.71 ~ p.74
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The Effect of Dexpanthenol in Postoperative Patients
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Hwang Mi-Ri
Kim Heung-Dae
Cho Dong-Ho
Han Won-Kon
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Abstract
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Purpose: The purpose of this study was to compare the efficacy of dexpanthenol in postoperative patients. Dexpanthenol, the alcohol derivative of pantothenic acid, is believed to be a precursor of acetylcholine through its incorporation into coenzyme-A.
Methods:From June 2005 to December 2005, 130 curative abdominal surgery, which were divided into a dexpanthenol group with 65 patients and a control group with 65 patients, were prospectively and randomly studied for recovery of bowel motility.
Results: No significant difference was found between the two groups as to incidence of postoperative ileus (16.9% vs. 15.4%, P=0.081), the time to flatus (77.2±38.4 vs. 77.9±31.9 hours, P=0.90), the time to defecation (5.3±2.7 vs. 5.1±2.6 days, P=0.77), the time to resumption of meals (7.9±4.0 vs. 8.9±4.2 days, P=0.17), and the duration of hospital stay (16.4±7.8 vs. 17.9±11.5 days, P=0.39).
Conclusion: Since no differences in the postoperative bowel motility were observed between the two groups, dexpanthenol is not recommended for general surgical use. J Korean Soc Coloproctol 2007;23:71-74
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KEYWORD
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Dexpanthenol, Postoperative ileus
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